MARINE ALGAE ENERGY POWERHOUSE
Facts on marine algae
- Algae are photosynthetic aquatic protists-eukaryotic organisms that are not animal, plants or fungi
- They share certain morphological and physiological characteristics with animals or plants or both
- The most abundant natural and versatile source of diverse bioactive compounds on Earth
- Drive production of adenosine triphosphate (ATP), metabolized through the complex process of cellular respiration, to fuel energy required activities
- Form organic food molecules from carbon dioxide and water via photosynthesis, biological process used by all cellular organisms, allowing to convert light into chemical energy
CHONDRACANTHUS TEEDEI
A WORLD OF POSSIBILITIES
Red Sicilian Algae
- Mount Etna, one of the world’s most active volcanoes in constant state of activity.
- Volcanic ash, carried by the wind, enriches soil with minerals and
nutrients and acts a multi-nutrient fertilizer. - Modifies aquatic system, enriches it with Nitrogen, Phosphorus,
Silicon, Iron and Zinc released in abundance
Benefits
- Red microalgae widespread in restricted areas of Eastern Sicily
- Cartilaginous membranous fronds
- Designed to survive in extreme environments
- Rich in carrageenans, high-molecular weight polysaccharides
- Rich in bioactive nutraceuticals as proteins, minerals, fatty acids and antioxidants
- Anti-fungal and Antiviral properties
- Highly beneficial for cosmetic formulations.
MARINE ALGAE APPLICATIONS
In Regenerative
Aesthetics
Abundant in polysaccharides, such as fucoidans in brown algae, ulvans in green algae and carrageenans in red algae, revealing a broad therapeutic potential and establishing the future generation of therapeutics.
Carrageenan-based hydrogels for wound-healing dressing materials (chitosan) showed enhanced healing effects in chronic wounds and showed more pronounced adhesive, antibacterial and drug delivery potential compared to other dressing
In Wound
Management
ALGAEX+
OUTSTANDING BIOREJUVENATION
- Repairs DNA
- Accelerates cell turnover
- Removes cell senescence
- Combats inflammation
- Rebuilds core skin structure
- Redensifies dermis
- Increases skin density and skin firmness
- Stimulates continuously collagen and elastin production
- Strengthens skin barrier
PRODUCT COMPOSITION
Hybrid ingredients
- 100 Billion Algae Exosomes
- Hyaluronic acid
- Medical Grade Bovine Gelatin
- PDRN
- Centella Reversa
- Palmitoyl Tripeptide-1
- Palmitoyl Pentapeptide 4
- Marine ExoPolySaccharide
- Vitamin B12
WHAT ARE EXOSOMES?
Exosomes are also known as Extracelular Vesicles (sEVs), membrane-bound extracellular vesicles (EVs) that are produced in the endosomal compartment of most eukaryotic cells. Naturally built up to carry “packs” of relevant biological information
- Lipid membrane-bounded extracellular vesicles of approximately 30-500 nm in diameter that are naturally secreted by
cells. - Contain DNA, RNA, lipids, proteins, cytokines, transcription factor
receptors, heat shock proteins, enzymes, antioxidants and other bioactive compounds. - Vital importance in intercellular in communication in both animals and plants.
- Regulation of gene transcription and translation
- Survival and proliferation
- Reproduction and development
- Angiogenesis and wound healing
- Waste management
- Host-microbiome interaction and viral immunity
- Balance of immune response and regulation of central and peripheral immunity
- Receptor-ligand signaling
- Apoptosis
- Cellular differentiation and neoplasia
- Cellular migration and metastatic disease
- Metabolic reprogramming and regulation
ALGAL DERIVED EXOSOMES
IN SKIN REJUVENATION
Best bioactives delivery system due to high content of Carrageenanans (natural linear sulfated polysaccharides).
High content of B-glucan, a carbohydrate immunoregulatory activity Membrane, rich in Beta proteins is easier to attach to the cells.
- Convey molecules, such as RNA/DNA, metabolites, proteins, and lipids
- Promote proliferation and migration of skin cells
- Play a major role in cell-to-cell communication
- Accelerate cells turnoverIncrease both, collagen synthesis and the expression of proliferation-associated proteins
- Excellent regeneration and rejuvenation ability
- Support skin homeostasis
- Quick healing and regeneration
- Antioxidant properties
- As powerful antioxidant
- Anti-inflammatory
- Microbiota modulation
EXOSOMES
FROM CENTELLA ASIATICA
Algaex formulation comprises high concentration Centella asiatica exosomes based on the patented Phyto-Peptidic Fractions (PPFs) technology.
PPF technology allows to:
- Harvest high yield of exosomes with a stronger potential to encapsulate and protect compounds
- Activate patterns of expression of cutaneous genes related to aging
- Improve skin barrier and hydration in keratinocytes (increased expression of type I collagen, inhibition of elastase, etc.)
- Regenerate and rejuvenate the skin
Small peptides with chains of 11-21 amino acids were identified in the exosomes of Centella asiatica cell cultures.
Centella Reversa brings together 30 of 87 existing peptide sequences (34.48%), with anti-ageing, anti-inflammatory, and anti-wrinkle activities, amongst others.
126 different proteins were identified in the supernatant of stem cells of Centella Asiatica.
REMARKABLE ANTI-AGEING EFFECT
Cellular Senescence
-
Cellular senescence is a complex process of biological cell long term loss of proliferative capacity;
-
Response to different internal and external stimuli such as telpmere attrition, DNA damage, mitochondria’ dysfunction, inflammation, apeing, lifestyle, environmental factors;
-
Senescent cells normally destroy themselves throuph a programmed mechanism calledapoptosis and getting removed by immune system;
-
Age and immuposuppressant environment hinder Immune system’s ability to work efficiently;
-
Senescent cells begin to accumulate in the tissues and continue to release chemicals that trigger chronic inflammation – one of the biggest contributors of aging.
Centella Reversa clinically proven to promote:
- Cell proliferation
- Cell detox
- DNA protection
- Cell reshaping
- Reversing the cell senescence
- Up to 14.6 years skin rejuvenation
- Rebuilding the core skin structure
Carrageenans
Act as immunomodulators and ROS scavengers, decreasing release of reactive oxygen species
IMPROVES SKIN STRUCTURE
STRUCTURE AND ELASTICITY
Building blocks of collagen
AMINO ACIDS
Vitally important proteins that create and fill cell structure, acting as building blocks of collagen, and resulting in instant skin bioregeneration.
Amino acids functions:
- Help keeping the skin plump and firm
- Work in tandem with the body’s water transport system to move moisture throughout the skin.
- Host biochemicals that protect against collagen damage.
- Reverse and repair existing collagen damage, caused by sun exposure.
PEPTIDES
Fragment of skin’s protein made up of amino acid, signaling dermis to synthesize
- Materials necessary to keep skin young and healthy.
- Act as collagen and elastin booster..
- Support stem cells and fibroblasts proliferation.
- Strengthening ESM and connective tissue.
- Prevent wrinkle formation & strengthen connective tissue.
- Exhibit high skin affinity.
MEDICAL GRADE GELATIN
- Highly purified biocompatible and biodegradable medical grade gelatin with endotoxin levels of (<10 endotoxin units (EUjg), 100 times lower than traditionally manufactured gelatins/ collagens.
- Biocompatible and biodegradable bovine gelatin mimics extracellular matrix, supports cell viability and function and paves the way for successful cell growth, differentiation and communication, resulting in significant improvement of skin’s firmness and elasticity.
UV RADIATION PROTECTION
Carrageenans are sulfated polysaccharides, found
in red marine algae in plenty
Role of Carrageenans
- Play important role in cellular photoprotective
mechanisms; - Improve immunomodulatory activities;
- ROS scavenging activities;
- Decrease UV-induced photodamage compared
with sunscreen alone; - Induce the expression of cyclooxygenase-2 (COX-2);
- Support COX-2 expression, important for
keratinocyte survival and proliferation after acute
UV irradiation.
Carrageenan has shown significant protection against the detrimental effects of UVB-induced apoptosis in HaCaT cells and has decreased the release of reactive oxygen species (ROS). The accumulation of excess ROS has been related to skin diseases including skin aging and cancers.
Photoprotective Substances Derived from Marine Algae by Ratih Pangestuti 1ORCID,Evi Amelia Siahaan 2 andSe-Kwon Kim*
ANTI-INFLAMMATORY ACTION
The inflammatory skin diseases, psoriasis and atopic dermatitis, show impaired barrier function.
Defects in lipid metabolism or in the protein components of the stratum corneum produce scaly or ichthyotic skin with abnormal barrier lipid structure and function.
- The carrageenans, are well known as immunomodulators
- High content of B-glucan, a carbohydrate with immunoregulatory activity
- Profound antifungal and antiviral activities
- Rich in bioactive nutraceuticals as proteins, minerals, fatty acids and antioxidants,
- Zinc, Silicon, Sulphur, Iron, Iodine, Calcium and Magnesium, working synergistically to fight inflammation and help skin to repair
- Soothing itchiness associated with irritation and skin conditions as acne and eczema.
- Combats inflammatory dermatitis by reducing T(H)2 cytokine production and supports healthy skin biome.
BUILDING WELL MOISTURIZED AND RESILIENT SKIN
MOISTURIZING
AND
HYDRATING
Acts as natural humectant, maintaining skin hydration by working at the molecular level to attract and retain water in the skin, hydrating and plumping the epidermis.
Retains moisture by reducing transepidermal water loss (TEWL), essential for maintaining skin hydration and ensuring a healthy skin barrier.
Enhances Natural Moisturizing Factor by supplementing the skin with abundant bioactive compounds, further improving the skin’s ability to retain moisture.
Superior moisture-retention.
Higher water retention capacity than hyaluronic acid.
STRENGTHENING
SKIN
BARRIER
Sun exposure, and the subsequent exposure to UV-A and UV-B rays together with harsh environmental factors are the biggest contributors, speeding up the aging of skin causing wrinkled, sagging, or rough skin that looks aged far beyond its years.
Algaex+ forms a high-density nano-thick film on the skin and when applied creates a mesh-like barrier on the skin, forming a second thin moisture film that:
- Protects against external stimuli and allergens.
- Builds an outstanding resilience against UV induced oxidative stress.
- Prevents appearance of consequent wrinkles, fine lines, or any textural problems that sun exposure can cause.
CLINICAL EVALUATION
WRINKLE
INTENSITY
WRINKLE
REDUCTION
TEXTURE
IMPROVEMENT
PORE
REDUCTION
SKIN FIRMNESS
IMPROVEMENT
Centella Reversa™ significantly increased the skin firmness at 28 and 56 days by up to 36% and 46% respectively compared to DO
(% Reduction of Ue = % Skin firmness increase). Cutometer® MPA-580
SKIN ELASTICITY
IMPROVEMENT
Centella Reversa™ significantly increased the skin elasticity at 28 and 56 days by up to 21% compared to DO
(% Increase of Ur/Uf = % Skin elasticity increase). Cutometer® MPA-580
D-BIOTECH S.R.L.
Via George Marshall Catlett, 5
Misterbianco (CT) 95045
Italy
+39 095 4038460
info@d-biotech.com
VAT IT05697890878
We’re committed to maintaining our leadership role in our industry, by subscribing to high standards of ethical conduct. We continually seek to ensure that the products and services we provide are ethically produced. D-Biotech is committed to ensuring that its staff and any workers it supplies (directly or indirectly) are not subject to behavior or threats that may amount to modern slavery, human trafficking, forced labour, and or similar human rights abuses.